ABOUT PDRN

What is PDRN?

PDRN is an acronym for polydeoxyribonucleotide, a DNA-derived component from Salmon trout (Oncorhynchus mykiss) or Chum salmon (Oncorhynchus keta) sperm cells with molecular weights between 50 and 1500 kDa. The DNA of these salmon species is very much similar to the human DNA. Thus, PDRN is highly biocompatible when administered into the body. PDRN is obtained through an extractive process at a high temperature to purify the substance and ensure a high percentage of salmon DNA or, better yet, the PDRN component. After extensive purification and extraction, PDRN comes in a mixture of purines, pyrimidines, nucleotides, and nucleosides with different chain lengths.

PDRN vs PN

PDRN is often used interchangeably with PN or polynucleotide due to their similar properties. However, they differ in their composition and extraction source. While PDRN is obtained from the sperm cells of salmon, PN is extracted from the testes. Polynucleotide is said to be more concentrated and has a higher molecular weight than PDRN. It also contains both DNA and RNA, while PDRN precisely consists of deoxyribonucleotides (DNA).

PDRN has been clinically proven helpful for various skin issues and is mainly considered one of the most innovative anti-aging treatments developed. It can stimulate cell migration and growth, produce extracellular matrix (ECM) protein, and reduce inflammation. Due to its tissue regeneration properties on the skin, it has also been the focus of wound healing treatments. It has also presented significant effects on scar prevention, inflammation, hyperpigmentation, and soft tissue regeneration. PDRN comprises therapeutic and cosmetic benefits that have earned it a distinction in the skincare industry.

What is Polynucleotide (PN)?

Polynucleotide (PN) is a next-generation injectable derived from long-chain DNA molecules, commonly sourced from purified salmon DNA. It is widely used in Korean aesthetic medicine for its ability to restore skin structure and promote deep regeneration.

While PDRN focuses on cell repair and healing, PN works at a more advanced level by improving the skin’s architecture and integrity. PN is commonly used to: